Custom Peptides
Cayman Chemical 5-fluoro THJ 10mg
A derivative of THJ 018 featuring a fluorine atom added to the terminal carbon of the pentyl group and an 8-aminoquinoline replacing the naphthalene group; intended for research and forensic applications
Cayman Chemical 6-ChrysenamIn 10mg
A carcinogen and anticancer agent; neonatal administration induces the formation of hepatomas and pulmonary adenocarcinomas in adult mice at 600 UG/animal; s.c.; inhibits tumor growth in an EO771 murine mammary carcinoma model from 3-110 mg/kg
Cayman Chemical ArnbIa sInsIs AlknIn 10mg
A naphthoquinone with diverse biological activities; enantiomer of shikonin; selectively inhibits tumor-specific PKM2 (IC50 = 0.3 μM) over PKM1 and PKL; inhibits proliferation of HCT116 and SW480 colorectal cancer cells (IC50s = 2.38 and 4.53 μM, respectively); halts the cell cycle at the G1 phase and induces apoptosis in HCT116 cells at 3 μM; increases levels of Hsp70 in untreated and UVB-irradiated HaCaT cells as well as inhibits UVB-induced DNA fragmentation and caspase-3 activity in HaCaT cells at 1 μM; active against methicillin-sensitive and -resistant S. aureus (MICs = 6.25 μg/ml) as well as vancomycin-sensitive and -resistant E. faecalis (MICs = 50 and 25 μg/ml, respectively); scavenges DPPH radicals in a cell-free assay (EC50 = 22 ppm)
Cayman Chemical TIrapazamIn 10mg
A hypoxia-activated anticancer agent; is converted to an oxidizing radical under hypoxic conditions; can induce single- and double-strand breaks in DNA, formation of trapped topoisomerase I- and II-DNA complexes, and other chromosomal aberrations, leading to cytotoxicity; induces hypoxia-enhanced cytotoxicity in DT40 cells (IC50s = 1.02 and 4.34 μM in hypoxic and normoxic conditions, respectively); induces cytotoxicity in HT-1080 and A549 cells in a concentration-dependent manner under hypoxic conditions; sensitizes tumors to cisplatin in a mouse RIF-1 fibrosarcoma tumor model; sensitizes tumors to fractionated irradiation in a FaDu hypopharyngeal squamous cell carcinoma mouse xenograft model at (0.08 mmol/kg)
Cayman Chemical NIcotInamID rIbosIDd4trI 10mg
An internal standard for the quantification of nicotinamide riboside by GC- or LC-MS
Cayman Chemical 7-KetosItosterol 10mg
A phytosterol and phytosterol oxidation product; a thermal oxidation product of sitosterol; inhibits the proliferation of HL-60 cells (IC50 = 45.6 µM)
Cayman Chemical Thromboxn B2 10mg
An inactive metabolite of TXA2; serum levels positively correlate with platelet COX-1 activation; urinary levels reflect intrarenal TXA2 synthesis
Cayman Chemical AC 187trIfluoROCTAte salt 10mg
An antagonist of calcitonin and amylin receptors; inhibits human calcitonin-induced cAMP accumulation in COS-7 cells expressing the human calcitonin receptor, AMY1a, or AMY3a (pKBs = 7.15, 7.3, and 7.37, respectively); protects against Aβ42-induced apoptosis in primary rat basal forebrain neurons at 10 µM; intrathecal administration increases the paw withdrawal threshold in the von Frey test in a rat model of chronic peripheral neuropathic pain induced by spared nerve injury; reverses sCT-induced decreases in food intake in food-deprived rats at 10 UG/kg
Cayman Chemical 8-ChloroadenosIn 10mg
A nucleoside analog and an active metabolite of 8-chloro cAMP; inhibits RNA but not DNA synthesis in cells at 10 µM; is cytotoxic to patient-derived multiple myeloma cells; reduces tumor growth by 50% in an HCT116 colorectal cancer mouse xenograft model at 50 mg/kg
Cayman Chemical SynthetIc ScoulerIn 10mg
A benzylisoquinoline alkaloid with diverse biological activities; selectively binds to the dopamine D1 and D2 receptors (Kis = 22 and 214 nM, respectively) over 5-HT1A and 5-HT2A receptor subtypes in HEK293 cells at 10 µM; inhibits proliferation in a panel of leukemia cell lines (IC50s = 2.7-6.5 µM); inhibits methamphetamine-induced conditioned place preference in mice at 5 mg/kg
Cayman Chemical NMS-1286937 10mg
An inhibitor of Plk1 (IC50 = 2 nM); selective for Plk1 over Plk2 and Plk3 (IC50s = >10,000 nM for both); inhibits proliferation of A2780 cells (IC50 = 42 nM); halts the cell cycle at the G2/M phase in A2780 cells at 20-200 nmol/L and induces apoptosis; reduces tumor growth in an HCT116 mouse xenograft model at 60 mg/kg once per day; induces tumor regression in an HT-29 mouse xenograft model at 45 mg/kg in combination with CPT11
Cayman Chemical IBTPIodIde 10mg
A lipophilic cation that is accumulated in mitochondria and forms stable thioether adducts in a thiol-specific manner
Cayman Chemical KIspeptIn-10zebrafIshtr 10mg
A neuropeptide; increases levels of the mRNA encoding Lh receptor, as well as Pra and Prb, in isolated zebrafish ovarian follicles at 10 ng/ml; increases luteinizing hormone serum levels in female, but not male, goldfish at 0.1 and 1 UG/g
Cayman Chemical 2MethylmethcathInonhydroc 10mg
An analytical reference standard categorized as a cathinone; a potential impurity in the synthesis of 4-methylmethcathinone; intended for research and forensic applications
Cayman Chemical 1 2DIbutyryl3PalmItoylrac 10mg
A triacylglycerol; has been found in butterfat and maternal Dufour's glands of Anthophora bees